Genetic variant associated with aggressive not indolent prostate cancer
نویسندگان
چکیده
منابع مشابه
Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.
Autopsy studies suggest that most aging men will develop lesions that, if detected clinically, would be diagnosed as prostate cancer (PCa). Most of these cancers are indolent and remain localized; however, a subset of PCa is aggressive and accounts for more than 27,000 deaths in the United States annually. Identification of factors specifically associated with risk for more aggressive PCa is ur...
متن کاملGenome-wide association study identifies a genetic variant associated with risk for more aggressive prostate cancer.
BACKGROUND Of the 200,000 U.S. men annually diagnosed with prostate cancer, approximately 20% to 30% will have clinically aggressive disease. Although factors such as Gleason score and tumor stage are used to assess prognosis, there are no biomarkers to identify men at greater risk for developing aggressive prostate cancer. We therefore undertook a search for genetic variants associated with ri...
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Recent studies have reported that the majority of prostate cancers express fusion genes in which the 5' region of the androgen-regulated TMPRSS2 gene is fused to an ETS family transcription factor, most commonly the ERG gene. We have characterized in detail the expression of TMPRSS2/ERG fusion mRNAs and correlated the isoforms expressed and expression levels with clinical outcome in cancers fro...
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In 2006, f234,460 men in the U.S. will be diagnosed with prostate cancer, and >27,000 deaths will be attributed to the disease (1). There is substantial phenotypic variability among cases and the disease incidence varies by age, race, and family history. In the U.S., f70% of all cases are z65 years at diagnosis, and the median age at diagnosis is 68 years (2). Several types of epidemiologic stu...
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Aggressive variant prostate cancers (AVPC) are a clinically defined group of tumors of heterogeneous morphologies, characterized by poor patient survival and for which limited diagnostic and treatment options are currently available. We show that the cell surface 78-kDa glucose-regulated protein (GRP78), a receptor that binds to phage-display-selected ligands, such as the SNTRVAP motif, is a ca...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2010
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.9.12.12137